BRCA1 and ovarian cancer: Finally, the number of family members eligible for the strategy, per year, was estimated at 2,045 individuals (6,150 cases of ovarian cancer per year multiplied by 19% of these cases related to BRCA1/2 germline mutation multiplied by 3.5 first-degree female relatives per patient with ovarian cancer, multiplied by 50% probability of transmission of the mutation).