Studies also showed that mutations in genes involved in NER, including excision repair cross-complementation group 2 (ERCC2) Lys751Gln 9, excision repair cross-complementation group 1 (ERCC1) C118T 10 and excision repair cross-complementation group 5 (ERCC5) Asp1104His 11, were associated with CRC. This evidence concerns the gene ERCC5 and colorectal carcinoma.