In terms of gene expression, transgenic expression of APOB in heart reduces lipotoxic cardiomyopathy in mice [30], but overexpression of FABP4 in cardiomyocytes aggravates cardiac hypertrophy in mice under pressure overload through activation of extracellular signal-regulated kinase (ERK) signaling [31]. Here, FABP4 is linked to cardiac hypertrophy.