Indeed, there is some evidence to support such a hypothesis in the neonatal mouse model, where increased levels of Muc5Ac expression detected at baseline in neonatal versus adult mice was shown to further increase in response to human rhinovirus infection.[19,20] Further work to determine the mechanisms contributing to this increase may yield new insights into the development of diseases such as asthma, in which goblet cell hyperplasia is a feature. The gene discussed is MUC5AC; the disease is asthma.