CD8A and heart disorder: The basal expression of the activation marker CD25 in CD8+ T cells was increased in IFN-γ nonproducers with cardiac disease compared with IFN-γ producers and uninfected subjects (Fig 6D), but the upregulation of CD25 after IL-7 stimulation was not drastically impaired in subjects who lacked IFN-γ-producing cells (Fig 6B).