CD36 and fatty liver disease: 2005; Huang et al. 2010), these transcription factors induce fatty liver disease via up‐regulation of CD36 expression. Interestingly, previous studies reported that PPAR‐γ and Nrf‐2 promote up‐regulation of CD36 expression in macrophages (Tontonoz et al. 1998; Ishii et al. 2004).