Thus, overexpression of BCL2 prevents cells from undergoing apoptosis, which contributes to the genesis and progressing of malignancy.34 Caspase‐3 has been recognized as one of the effector caspases in cell apoptosis.35 Activation of caspase‐3 and its downstream factors by honokiol indicated an apoptosis‐regulating function of honokiol in lung SCC, which is considered as a protective mechanism against cancer progression.36 Our study indicated that honokiol administration could downregulate BCL2 expression, promote the caspase‐3 signaling pathway, and accelerate cell apoptosis. The gene discussed is BCL2; the disease is cancer.