MAPT and memory impairment: This was supported by several studies showing that AD‐like pathologies, such as memory impairment, hyperphosphorylated tau, neurofibrillary tangles, and Aβ plaques, were improved using OGA inhibitor for modulation of autophagy and the O‐GlcNAcylation of tau, and Nicastrin, one of γ‐secretase components (Kim et al., 2013; Graham et al., 2014; Yuzwa, Cheung, Okon, McIntosh, & Vocadlo, 2014; Yuzwa, Shan, et al., 2014; Zhu et al., 2018).