Cbl‐b, a member of the Cbl protein family, functions as an E3 ubiquitin‐protein ligase, which binds with activated tyrosine kinases, such as the EGFR, for lysosomal degradation leading to cellular responses including cell proliferation, motility/migration and invasion.18, 19 Combining the above results, it implicates a possibility that DUXAP9‐206 may promote NSCLC progression by directly binding with Cbl‐b to reduce the degradation of EGFR. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.