Mitogen‐activated protein kinase is a critical sensor of cellular proliferation and differentiation.21 MAPK overexpression or up‐regulation of its activity has been linked to cancer.21 MAPK has emerged as a central feature of EMT program in LC.14 Moreover, accumulating evidence indicates that ERK activation play an active role in cancer cell growth and invasion through EMT.22, 23 In this study, we observed that down‐regulation of TRIM59 significantly attenuates ERK signalling in H1299 and A549 cells. This evidence concerns the gene TRIM59 and cancer.