The CDK 6 control the G1 phase of the cell cycle, which has a central role in cell proliferation and in tumourigenesis.9, 10 It is widely accepted that CDK6 is a leading gene relating to tumour growth and metastasis.11 Therefore, further investigation of the above association of TRIM59 and CDK6 is of pivotal importance. This evidence concerns the gene TRIM59 and neoplasm.