Our previous findings that Nurr1 is highly expressed in the subiculum and the frontal cortex in 5XFAD mice showing the highest levels of amyloid deposition (Moon et al., 2015) suggested a functional link between Nurr1 and Aβ‐mediated pathology of AD, but did not clarify the nature of the mechanistic link. Here, NR4A2 is linked to Alzheimer disease.