NR4A2 and Alzheimer disease: In addition, other recent studies have reported that the expression level of Nurr1 is significantly diminished in amyloid beta (Aβ)‐treated neuronal cells (Terzioglu‐Usak, Negis, Karabulut, Zaim, & Isik, 2017), animal models (Espana et al., 2010; Parra‐Damas et al., 2014), and in postmortem brains of human AD patients (Parra‐Damas et al., 2014).