The highly expressed NLRP6 in mouse IEC plays an important role in protecting against the development of enteritis by regulating the stability of the intestinal mucosal barrier.17, 22, 23, 24 Therefore, clarifying the factors regulating NLRP6 or identifying the ligands for NLRP6 could shed light on adaptation of the intestine when exposed to microbes. The gene discussed is NLRP6; the disease is enteritis.