Muc2 mucin is a large glycoprotein produced by goblet cells that forms the first line of innate host defence.47 Muc2‐deficient (Muc2−/−) mice develop spontaneous colitis and cannot prevent attachment and removal of adherent pathogens from the mucosal surface.48 After inoculating Muc2−/− mice with C. rodentium, a murine A/E pathogen related to diarrhoeagenic A/E. coli, there was 10‐100‐fold greater C. rodentium burden in Muc2−/− than in WT mice.49 NLRP6 is highly expressed throughout the intestinal mucosa, specifically in goblet cells. Here, NLRP6 is linked to colitis.