NLRs are composed of 23 family members in the human genome and 34 in the mouse genome.14 In recent years, Ranson et al15 observed that the inflammasome component NLRP6 is up‐regulated in human ileal Crohn's disease(CD), but not to a significant extent in human ulcerative colitis. This evidence concerns the gene NLRP6 and ulcerative colitis.