Functional NLRP6 inflammasomes lead to proteolytic cleavage and activation of caspase‐1, after which the proinflammatory cytokine IL‐18 is released.18 To assess the possibility that NLRP6 might have an influence on colitis, NLRP6−/− mice were used in several studies.14, 34, 35, 36 In this model, NLRP6‐deficient mice displayed enhanced susceptibility to DSS‐induced colitis. This evidence concerns the gene IL18 and colitis.