NLRP6 and colitis: The thick mucous layer is a key component that defends the lamina propria against being penetrated by microbes and pathogens.44 In UC patients and in mice with DSS‐induced colitis, there was often depletion of recognizable goblet cells, decreased mucus synthesis and secretion in the colonic epithelium.45, 46 In an enteric pathogen clearance experiment, Wlodarska et al29 observed increased C. rodentium burden and pathological changes in NLRP6‐deficient mice compared with those of WT mice.