As discussed earlier, 2 global phase 3 trials in patients with previously treated advanced GC/GEJC (KEYNOTE-061 and JAVELIN Gastric 300) that compared anti-PD-1/PD-L1 antibody treatment (pembrolizumab or avelumab) with standard second-line or third-line chemotherapy did not meet their primary endpoints [22, 30]. The gene discussed is PDCD1; the disease is gastric cancer.