PDCD1 and gastric cancer: In a recent phase 3 trial in 493 patients with advanced GC performed in Japan, South Korea, and Taiwan (ATTRACTION-2), nivolumab (anti-PD-1) administered as third- or later-line treatment was associated with longer overall survival (OS) than placebo (median, 5.26 vs 4.14 months; P < 0.0001); objective response rates (ORRs) for nivolumab vs placebo were 11.2% vs 0%, respectively [20].