Some researches proved the Snail-mediated EMT which can inhibit the apoptosis of MDCK cells by downregulating the expression of caspases and Spermatogenic Zip 1 (SPZ1)-Twist complex could act as a protooncogene, and improve VEGF expression via the recruitment of BRD4, thus promoting RNA-Pol II-dependent transcription and inducing tumor metastasis [26, 27]. This evidence concerns the gene SPZ1 and neoplasm.