EPCAM and neoplasm: EMT in tumor cells is a highly complex dedifferentiation process, speculated to participate in the metastatic cascade, during which the epithelial markers such as cytokeratins, E-cadherin, and epithelial cell adhesion molecule (EpCAM) are downregulated, while the mesenchymal markers such as fibronectin, vimentin, and N-cadherin are upregulated [20].