Notably, the expression of fibrinogen receptor GPIIb-IIIa (αIIbβ3 integrin) and P-selectin on the platelets mediate the attachment of platelets and CTCs that express the membrane surface molecules such as αvβ3 integrin and the cell adhesion molecule CD44, indicating a robust correlation with tumor dissemination [34, 36, 37]. This evidence concerns the gene CD44 and neoplasm.