MTOR and Hereditary breast cancer: Indeed, the top five canonical pathways associated with the MII versus EGA stage were the EIF2 signalling (p=1.1E-26), the protein ubiquitination pathway (p=6.6E-20), the regulation of eIF4 and p70S6K signalling (p=2.1E-14), the hereditary breast cancer signalling (p=7.3E-9), and the mTOR signalling (p=4.9E-08) (Figure 1(b)).