Conversely, TNFRSF10B is expressed in human blastocysts [55] and induces apoptosis in mouse blastocysts [56]. TP53 also was upregulated at this stage. TP53 encodes a tumour suppressor that maintains genomic stability in response to internal and external stress signals through the regulation of several processes, including apoptosis induction. Here, TNFRSF10B is linked to neoplasm.