After 3 days of HAE, the values of BAL fluid levels of MPO (100 μg/ mg protein versus 300 μg/mg protein), IL-6 (8 pg/mL versus 49 pg/mL), IL-1β (12 pg/mL versus 65 pg/mL), and TNF-α (6 pg/mL versus 49 pg/mL) in the HAE+non-HBO2T group were significantly higher than those of the non-HAE+non-HBO2T group (P<0.05, n=12 each group) (Figure 7). Here, IL1B is linked to hereditary angioedema.