Cancer-Associated-Fibroblast (CAF)-derived microvesicles, containing oncomiR-221 promoted de novo endocrine resistance—as overexpression of oncomiR-221/222 in luminal breast cancer cells reduces ER expression (182) Furthermore CAFs can promote the cancer stem cell phenotype by secreting CCL2, inducing Notch1 (183). This evidence concerns the gene CCL2 and cancer.