Patients were more likely to have a severe NIHSS at discharge (>15) when presenting with low ASPECT at CTP (p=0.03), low CBS (p=0.04), bad collaterals (PAF) (p=0.025), and long time from symptoms onset to IV tPA (p=0.04) rather than a moderate-mild stroke (Table 4). The gene discussed is CBS; the disease is stroke disorder.