Several studies support the implication of the well known Hepatocyte Growth Factor (HGF) Receptor, C-Met in the regulation of the metastatic dissemination in a wide variety of malignancies including hepatocellular carcinoma [6], lung [7], breast [8] and colon cancers [9], as well as Osteosarcoma [10]. The gene discussed is MET; the disease is osteosarcoma.