Adrenal Insufficiency (AI) may be caused by destruction or dysfunction of the adrenal gland (primary AI, Addison's disease), deficient pituitary adrenocorticotrophic hormone (ACTH) secretion (secondary AI), or deficient hypothalamic secretion of corticotropic releasing hormone (CRH) (tertiary AI). Here, POMC is linked to Adrenal insufficiency.