However, functional annotation performed in vitro pointed similarities to most-DILI risk – demonstrated through genes such as Magee1. Magee1 was modulated in vitro only by compounds in the most-DILI group, and associated to “Liver Cirrhosis, Experimental” according to DisGeNET data; in vivo, it was found in a module associated with hepatobiliary outcomes (Sutherland et al., 2017). This evidence concerns the gene MAGEE1 and cirrhosis of liver.