Among the enriched TFs of dark genes in the most-DILI group, we detected, for instance, E2F1, which has been demonstrated to be involved in liver fibrosis, a common end-point of compound-induced liver injury (Zhang Y. et al., 2014), as well as JUND in the inflammatory process in liver (Seki et al., 2012). This evidence concerns the gene JUND and Hepatic fibrosis.