E2F1 and Hepatic fibrosis: Among the enriched TFs of dark genes in the most-DILI group, we detected, for instance, E2F1, which has been demonstrated to be involved in liver fibrosis, a common end-point of compound-induced liver injury (Zhang Y. et al., 2014), as well as JUND in the inflammatory process in liver (Seki et al., 2012).