To check for the possible signs of systemic inflammation, we measured the concentration of inflammation-associated cytokines (TNF-α, IFN-γ, IL-1b, IL-1Ra, IL-2, IL-5, IL-6, CXCL8, CXCL10, G-CSF, and GM-CSF) in the plasma of vitiligo patients. This evidence concerns the gene TNF and vitiligo.