To better explore the impact of stable BCL10-CARD11 fusion on NF-κB activation, we switched to GCB DLBCL derived BJAB B cells, which under basal conditions are devoid of NF-κB activity, but overexpression of oncogenic CARD11 mutants induces strong chronic NF-κB activity (5, 6, 25). This evidence concerns the gene NFKB1 and diffuse large B-cell lymphoma.