In BJAB B cells stable BCL10-CARD11 expression activates MALT1 and NF-κB as strong as oncogenic variants of CARD11 derived from DLBCL tumor patients (5, 6, 25, 26), clearly showing that the proximity of BCL10 and CARD11 alone is sufficient to activate downstream signaling pathways. Here, NFKB1 is linked to diffuse large B-cell lymphoma.