Jurkat CARD11 or BCL10 KO T cells were reconstituted by lentiviral transduction and comparable infection rates for epitope-tagged (FS: Flag-StrepTag2) CARD11 and BCL10 constructs were obtained, as determined by co-expression of the surface marker ΔCD2 (Supplementary Figures 3A,B). Here, CARD11 is linked to infection.