SIRT5 and peritonitis: In a model of acute peritonitis induced by E. coli, bacterial dissemination into the blood (SIRT5+/+ vs. SIRT5−/−: 2.3 ± 1.3 × 108 CFU/ml vs. 3.8 ± 2.0 × 103 CFU/ml; mean ± SEM; P = 0.4) and mortality rate (73 vs. 91%, P = 0.6) were comparable using SIRT5+/+ and SIRT5−/− mice (Figure 6C, plain lines).