During acute listeriosis, SIRT5+/+ and SIRT5−/− mice displayed similar bacteremia (SIRT5+/+ vs. SIRT5−/−: 4.1 ± 2.2 × 103 CFU/ml vs. 4.8 ± 3.6 × 103 CFU/ml; mean ± SEM, P = 0.8) and survival rate (P = 0.9) (Figure 7A, plain lines). The gene discussed is SIRT5; the disease is bacterial infectious disease with sepsis.