Analogous to what observed upon challenge with low inocula of K. pneumoniae, E. coli and L. monocytogenes (Figures 6A,C, 7B), SIRT5+/+ and SIRT5−/− mice were similarly resistant to sublethal staphylococcal infection (Figure 7B, dashed lines) suggesting that SIRT5-deficient mice are not particularly susceptible to bacterial infections. The gene discussed is SIRT5; the disease is bacterial infectious disease.