CTAG1B, BRCA2, and SPAG8 have been previously shown to induce humoral immune response in BC (27–29) and other cancer patients (25, 27, 30), ANKRD30BL and COPS4 were previously found to elicit autoantibody response in gastric and thyroid cancer and melanoma (24, 26). This evidence concerns the gene SPAG8 and cancer.