IgA-TAA score was significantly higher in ER and PR-negative cancers than in the hormone receptor-positive cancers (mean FC = 2.80, P = 0.027, FC = 2.25, P = 0.028) and was higher in grade 3 than grade 2 cancers (mean FC = 2.22, P = 0.013; Figure 2B). The gene discussed is ESR1; the disease is cancer.