FHL2 and viral infectious disease: Analogous to FHL2 patients, perforin-deficient (Prf1−/−) mice develop lethal inflammation after viral infection; in this murine model of FHL2, uninhibited replication of lymphocytic choriomeningitis virus (LCMV) induces pathologic accumulation of LCMV-specific CD8+ T cells and interferon-γ (IFNγ) (5–7).