Recently, Lu et al. (2016) reported that BEA induces NSCLC A549 cancer cell apoptosis through the mitogen-activated protein kinase pathway (MAPK), BEA can also activate MEK1/2-ERK42/44-90RSK crosstalk signaling pathway which can induce A549 cell cycle arrest in the S phase and apoptosis (Lu et al., 2016). The gene discussed is MAP2K1; the disease is cancer.