HSPA5 and subarachnoid hemorrhage: The neuronal functions of GRP78 have been investigated in various central nervous system (CNS) disease models, including ischemic insults (Wang et al., 1993; Aoki et al., 2001; Ito et al., 2001; Shibata et al., 2003; Tajiri et al., 2004; Oida et al., 2008; Osada et al., 2010), epileptic seizures (Wang et al., 1993; Chen et al., 2013), spinal cord injury (Penas et al., 2007, 2011; Ohri et al., 2012; Matsuyama et al., 2014), diabetic encephalopathy (Zhao et al., 2015), and experimental subarachnoid hemorrhage (Liu et al., 2016).