We also found that mRNA expression levels of CDH1, CDKN1A, and EP300 were significantly reduced while those of RhoA, ROCK1, ROCK2, PIK3CA, and CCND1 were significantly increased in gastric cancers with reduced or loss of NKX6.3 expression compared to those in NKX6.3 positive cases (Fig. 6C). The gene discussed is CCND1; the disease is gastric cancer.