The mCAF subset of the tumor stroma specifically expressed transcripts of a large variety of ECM-related genes, such as glycoproteins (Dcn, Lum, and Vcan), structural proteins (Col14a1), matricellular proteins (Fbln1, Fbln2, and Smoc), and matrix-modifying enzymes (Lox and Loxl1) (Fig. 3e). This evidence concerns the gene VCAN and neoplasm.