The OR of the T allele under the recessive model was higher in the HLA-B*51 carriers than in the whole population for all of the clinical manifestations except for cardiac involvement, and the homozygous TT genotype was significantly associated with the risk of arthritis in HLA-B*51 positive patients (P = 0.0013, OR = 2.54). The gene discussed is HLA-B; the disease is Arthritis.