To link BST-2 expression in breast tumors to tumor aggressiveness, we performed BST-2 immunohistochemistry (IHC) using tumor tissues obtained from an unselected, hospital-based cohort of patients (n = 79) with invasive breast cancer (IBC) diagnosed at The University of Iowa between 1986 and 198929. The gene discussed is BST2; the disease is invasive breast carcinoma.