In a model of unilateral ureteral obstruction, the deletion of ACE2 gene resulted in a four-fold increase in the ratio of intrarenal Ang II/Ang-(1-7) and these changes were associated with tubulointerstitial fibrosis and high levels of TNF, IL-1β and MCP-1 [29]. The gene discussed is IL1B; the disease is Ureteral obstruction.