NPHS1 and Nephropathy: To corroborate this hypothesis, Han et al. [43] previously reported that rats submitted to puromycin-induced nephropathy and to anti-nephrin antibody-induced nephropathy when treated with anti-IP-10/CXCL-10 function-blocking antibody displayed a decrease in the protein level of slit-diaphragm components and exacerbated proteinuria [43].