CD19 and diffuse large B-cell lymphoma: On October 18th, 2017, the FDA granted a second CAR T therapy approval to the CD28-based CD19 CAR T cell product axicabtagene ciloleucel (Axi-cel, Yescarta, Kite Pharma/Gilead, Los Angeles, CA) for the treatment of patients with DLBCL who have not responded or have relapsed after two prior treatment regimens [9].