In particular, a multifaceted response to tumor antigens released following necrosis and apoptosis results from exposure to PAMPs, danger associated molecular patterns (DAMPs: such as heat shock proteins, uric acid, calreticulin, HMGB-1), and cytokines (such as IFN 1, interleukin 12, and TNF α). This evidence concerns the gene HMGB1 and neoplasm.