DMTN and Familial prostate cancer: Consistent with our results, Lutchman, M, et al. observed a frequent loss of DMTN in prostate cancer, even for metastatic high-grade prostate cancer, using fluorescent in situ hybridization (FISH), and concluded that the role of DMTN in tumorigenesis may be similar to that of the tumor suppressor gene NF2 in neurofibromatosis based on DMTN functional studies [32].