ARHGEF4 and neoplasm: Considering the above results, we speculate that the dysregulation of DMTN may function as a tumor suppressor gene by regulating the activity of Rac1 signaling in the carcinogenesis, invasion and metastasis of CRC, which may be similar to the effect of truncated mutant adenomatous polyposis coli (APC) on the activation on Rac1 by relieving binding with Asef and Asef2 [33, 34].