The results from the orthotopic mouse metastatic model showed that the overexpression of DMTN decreased tumor numbers and the frequency of liver metastasis (Fig. 2e, P < 0.05), and DMTN overexpression also extended the overall survival time of the nude mice injected with the CRC cell lines (Fig. 2f, P < 0.05). Here, DMTN is linked to colorectal carcinoma.