The results suggested that the “RHO_GTPASES” and “Rac1 signaling pathways” gene sets were significantly enriched in CRC tissues with low DMTN expression in GSE13067, GSE13294 and GSE7208 (Fig. 3a and Additional file 1: Figure S3A, P < 0.05). Here, RAC1 is linked to colorectal carcinoma.