TSPAN1 and hepatocellular carcinoma: Recently, TSPAN1 was reported to accelerate many kinds of cancer progression, especially digestive malignancies such as hepatocellular carcinoma (HCC), pancreatic, gastric, colorectal, and esophageal cancers [3–7], and some other non-digestive cancers such as osteosarcoma and cervical cancer [8, 9].