AKT1 and hepatocellular carcinoma: For example, Herlevsen et al. [36] found that the association of TSPAN8 with α6β4 integrin supported cell motility and liver metastasis formation, and Ai et al. [26] discovered that TSPAN24 interacted with Integrin α6β1 to amplify PI3K/AKT signaling to induce EMT in HCC.