VHL and renal cell carcinoma: As shown in Fig. 2, NKs derived from VHL-MUT patients (#24, #25, #26) displayed higher CD107a exposure versus RCC autologous tumor cells or A498-VHL-MUT cells as compared to SN12C-VHL-WT cells (average CD107a+NK: 4.7 and 2.7% vs 0.3% respectively at 10E:1 T ratio).