Similar results were obtained when IL-2 activated whole blood samples from VHL-MUT-RCC patients (n = 5) were evaluated toward another VHL-MUT RCC cell line, 786-O cells (MHC-I expressing cells, Additional file 2: Figures S1-S2A) carrying a single mutation in VHL exon 1 (1-nt deletion at nt 523) [26] different from A498 cells. Here, VHL is linked to renal cell carcinoma.