Interestingly, high percentage of NK cells expressing CD107a was observed for blood derived from VHL-MUT-RCC patients against A498-VHL-MUT cells and not versus CAKI-1-VHL-WT cells (average CD107a+NK: 7 ± 2% vs 1 ± 0.41% respectively, p = 0.015, Fig. 1C). The gene discussed is VHL; the disease is renal cell carcinoma.