Using whole-exome sequencing and targeted sequencing, recurrent somatic gene mutations are identified in NKTCL, mainly as RNA helicase gene DDX3X, tumor suppressors (TP53, MGA, and BCOR), janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway molecules (JAK3, STAT3, and STAT5B), and epigenetic modifiers (MLL2, ARID1A, EP300, and ASXL3) [9, 14]. Here, STAT5B is linked to extranodal nasal NK/T cell lymphoma.