Findings showed that women with COPD-BS have distinct profile of adipokInes, incretins, and peptide hormones, with hyperinsulinemia and hyperglycemia, compared with women with COPD-TS, which might confer a major risk of develop T2DM in these women, being it supported especially by the increment in ghrelin, insulin, PAI-1, and visfatin, which were associated with the exposure to BS. This evidence concerns the gene INS and Hyperinsulinemia.