Our data also support the role of visfatin as an adipokine that favors the prevalence of systemic inflammation, impairing in the pulmonary diffusing capacity, and decline in the pulmonary function; which was higher in COPD-BS women, and might be responsible, in part, of the systemic inflammatory effect induced by visceral adipose tissue, that is the more pernicious subcutaneous adipose tissue. The gene discussed is NAMPT; the disease is chronic obstructive pulmonary disease.