Thus, to determine the possible causes of the increment of the peptide hormones, adipokines, and incretins, and consequently, the possible develop of T2DM in COPD; multivariable analysis was assessed to know if it really was the exposure to biomass responsible for the changes observed in petidic hormones, adipokines and incretins, the variables were: FEV1% pred, age (years), BMI, and biomarkers of MS and T2DM. This evidence concerns the gene GCG and type 2 diabetes mellitus.