Considering that the BMI showed no difference between the groups of COPD, it might evidence that BMI in not determinant to the develop of systemic inflammation in COPD-BS; thus, the role of ghrelin, insulin, leptin, PAI-1, and visfatin in women exposed to BS seems take an important physiopathogenic role in the develop of systemic inflammation in COPD in this women. This evidence concerns the gene GHRL and chronic obstructive pulmonary disease.