SOX30 is a key metastatic suppressor with inhibition of Wnt/CTNNB1-signaling by directly binding to CTNNB1 promoter to prolong the survival of ADC patients, whereas SOX30 plays no inhibitory role on tumor-metastasis without suppression of Wnt/CTNNB1-signaling duo to not binding to CTNNB1 promoter resulting in short survival of SCC patients (Fig. 7d). This evidence concerns the gene CTNNB1 and AIDS dementia complex.