These CNAs included the loss of CFA22 within RB1 (retinoblastoma tumor suppressor) gene in both tumors, and the loss of CFA26 within PTEN (phosphatase and tensin homologue) gene associated with the loss of a region of CFA11, including CDKN2A (cyclin-dependent kinase inhibitor 2A) in the Dog_2 tumor. The gene discussed is RB1; the disease is neoplasm.