All the samples were wild type for Mitf (E378), Braf (V595), Gna11, Nras (G12 and Q61), Gnaq and p53. However, no amplification of the 11 exons of TP53 was found in Dog_1-derived tumor and Ocr_OCMM1 cells, which was unexpected. The gene discussed is BRAF; the disease is neoplasm.