Several oncogenes are known to be linked to melanomagenesis, such as Braf, Nras, Gna11, Gnaq, Mitf and p53. Mutations in these genes are described in human cutaneous melanoma (BRAF, NRAS), mucosal melanoma (NRAS), blue nevi and uveal melanomas (GNAQ, GNA11) and in numerous other cancers (TP53) [17]. The gene discussed is TP53; the disease is cutaneous melanoma.