These findings were confirmed by the evaluation of the cytoplasmic expression of Melan-A, which was found to be positive in the xenograft tumor samples (Fig. 6c, d) and the xenograft-derived isolated cell lines Ocr_OCMM1X and Ocr-OCMM2X (Fig. 7c, d and Additional file 4B). This evidence concerns the gene MLANA and neoplasm.