Although the expression of netrin-associated receptors including ITGA6 and ITGB4, is regulated by various growth factors, especially by Epidermal growth factor/Epidermal growth factor receptor EGF/EGFR [26–29], the upstream regulators of NTN4 expression and of GBM cell senescence remain largely unknown. The gene discussed is ITGB4; the disease is glioblastoma.