In addition, the rs738409 variant was identified as an independent predictor of HCC occurrence pointing out for the first time a role of the I148M PNPLA3 variant in the risk of HCC (OR = 1.76; p < 0.05) also in non-drinking alcoholic cirrhosis [12,66,67]. This evidence concerns the gene PNPLA3 and hepatocellular carcinoma.