Patients with alcohol-related cirrhosis who carry the rs58542926 TM6SF2 variant have an additional risk factor for the development of HCC and carriage of both PNPLA3 rs738409 and TM6SF2 rs58542926 accounts for half of the attributable risk for HCC in this population [72]. This evidence concerns the gene PNPLA3 and hepatocellular carcinoma.