The positive association between the rs58542926 variant and the amount of hepatic triglyceride content remained significant even after adjustment for the PNPLA3 rs738409 genotype, indicating that the E167K variant’s effect on steatosis onset is independent of PNPLA3. Additionally, carriers of the rs58542926 showed lower circulating lipids and a reduced cardiovascular risk [78]. Here, PNPLA3 is linked to steatosis.