Finally, the rs2228603 (c.274 C>T, p.Pro92Ser) in Neurocan (NCAN) gene, commonly associated with NAFLD, has further been identified to represent an independent risk factor for HCC onset even in patients affected by alcohol-related cirrhosis (OR = 1.840; 95% CI = 1.220–2.777; p = 0.004), displaying a 15.1% of frequency in ALD-HCC subjects [104]. Here, NCAN is linked to metabolic dysfunction-associated steatotic liver disease.