In a very recent paper, Stickel et al. found that the development of HCC was independently associated with rs738409 PNPLA3 (OR = 1.84 [CI 95%: 1.55–2.18]) and rs58542926 TM6SF2 (OR = 1.66 [CI 95%: 1.30–2.13]) variants. The gene discussed is PNPLA3; the disease is hepatocellular carcinoma.