They have also been investigated for biological activities such as cytotoxic [18,19,20,21], anti-tumor [22,23], antimicrobial [24,25,26], anti-inflammatory [27,28,29], platelet-aggregation inhibitory [30,31], and farnesoid X receptor (FXR) antagonistic [32,33] activities. This evidence concerns the gene NR1H4 and neoplasm.