HA interacts with a range of cell surface receptors, including cancer stem cell marker CD44, receptor for hyaluronan-mediated motility (RHAMM), toll like receptors 2 and 4 (TLR2, TLR4), hyaluronan-binding protein 1 (HABP1), hyaluronan receptor for endocytosis (HARE) and lymphatic vessel endothelial receptor for hyaluronan 1 (LYVE1). The gene discussed is TLR2; the disease is cancer.