Activation of growth factor regulating signalling pathways (insulin- like growth factor (IGF), epidermal growth factor (EGF), hepatocyte growth factor (HGF)), cell differentiation related pathways (Wnt, Hedgehog, Notch) and angiogenesis-induced signalling pathways (vascular endothelial growth factor) also promotes HCC pathogenesis [19]. Here, EGF is linked to hepatocellular carcinoma.