NFE2L2 and hepatocellular carcinoma: p62 activated Nrf2 by degrading Keap1, which eventually triggered the transcription of Nrf2-target genes-Nqo1, HO-1 and FTH1. These Nrf2-target genes reduce the lipid peroxidation and regulate iron homeostasis in HCC, thereby conferring resistance against ferroptosis.