In an MS model, experimental autoimmune encephalitis (EAE) [6], AHR KD increased disease scores, while the activation of AHR with AHR agonists, such as TCDD, indole-3-carbinol (I3C), and diindolylmethane (DIM), suppressed EAE disease progression through increased Forkhead Box P3 (FOXP3) expression, increased anti-inflammatory regulatory T cells (Treg), and decreased pro-inflammatory Th17 expansion [6,14,18,42]. Here, AHR is linked to myeloid sarcoma.