U2AF1 and acute myeloid leukemia: Indeed, 63% of SRSF2 mutated s-AML are also mutated for ASXL1. The latter is also frequently associated with EZH2, ZRSR2, STAG2, and U2AF1. Being one of the most commonly CHIP-associated gene [6], ASXL1-repeated association with the other genes makes sense from a statistical point of view, but also, from a clinical perspective, because MDS principally occurs in elderly patients who are mostly affected by CHIP.