These subgroups include acute promyelocytic leukemia with t(15;17) (PML-RARA), AML with t(8;21)(q22;q22.1) (RUNX1-RUNX1T1), AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22) (CBFB-MYH11), AML with t(9;11)(p21.3;q23.3) (MLLT3-KMT2A), AML with t(6;9)(p23;q34.1) (DEK-NUP214), AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2) (RPN1-MECOM), and AML with t(1;22)(p13.3;q13.3) (RBM15-MKL1). The gene discussed is PML; the disease is acute myeloid leukemia.