BCR-ABL-negative myeloproliferative neoplasms (MPN), represented by polycythaemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), can evolve during the course of the natural history of the disease to what is called blast-phase, which is namely, s-AML to MPN (Figure 1C). This evidence concerns the gene ABL1 and acquired polycythemia vera.