Interestingly, a mutually exclusive relationship was found between SRSF2 mutations and those in the DNMT3A and EZH2. Regarding SF3B1 mutations, they were less associated to the other lesions, apart from DNMT3A and JAK2, and occurred mainly in MDS with ring sideroblasts (MDS-RS). Here, SRSF2 is linked to myelodysplastic syndrome.