Eight genes involved in three functional groups were found to be specifically associated with s-AML: RNA splicing for SRSF2, U2AF1, ZRSR2 and SF3B1, chromatin modifiers for BCOR, ASXL1, and EZH2, and cohesin complex for STAG2. The most frequently-mutated genes are ASXL1 (32%) and SRSF2 (20%), which also correspond to the most frequent association, between the eight genes. Here, EZH2 is linked to acute myeloid leukemia.