Papaemmanuil et al. [2] established a new AML sub-entity called TP53-aneuploidy, which encompasses TP53 mutations, complex karyotype, and chromosomal copy-number alterations, such as −5/5q, −7/7q, −17/17p, −12/12p, +8/8q for the most frequent and the most repeatedly associated with TP53 mutations (Figure 1A–C). Here, TP53 is linked to acute myeloid leukemia.