NUCB2 and major depressive disorder: Since circulating NUCB2/nesfatin-1 levels have been reported to be elevated in patients with depression [49] or to be correlated with reported levels of depressive behavior [50] along with the finding that also high doses of nesfatin-1 injected intraperitoneally induce anhedonia in rats [51], peripheral nesfatin-1 might well be involved in the development and/or maintenance of depressive symptoms such as reduced appetite [27].